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  • Evaluation and Forecasting of Wind Energy Investment Risk along the Belt and Road Based on a Novel Hybrid Intelligent Model
  • Abstract The timely and effective investment risk assessment and forecasting are of great significance to ensure the investment safety and sustainable development of wind energy along the Belt and Road. In order to obtain the scientific and real-time forecasting result, this paper constructs a novel hybrid intelligent model based on improved cloud model combined with GRA-TOPSIS and MBA-WLSSVM. Firstly, the factors influencing investment risk of wind energy along the Belt and Road are identified from three dimensions: endogenous risk, exogenous risk and process risk. Through the fuzzy threshold method, the final input index system is selected. Secondly, the risk evaluation method…
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  • Study of Degenerate Poly-Bernoulli Polynomials by λ-Umbral Calculus
  • Abstract Recently, degenerate poly-Bernoulli polynomials are defined in terms of degenerate polyexponential functions by Kim-Kim-Kwon-Lee. The aim of this paper is to further examine some properties of the degenerate poly-Bernoulli polynomials by using three formulas from the recently developed ‘λ-umbral calculus.’ In more detail, we represent the degenerate poly-Bernoulli polynomials by Carlitz Bernoulli polynomials and degenerate Stirling numbers of the first kind, by fully degenerate Bell polynomials and degenerate Stirling numbers of the first kind, and by higherorder degenerate Bernoulli polynomials and degenerate Stirling numbers of the second kind.
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  • Nitric oxide and hydrogen sulfide share regulatory functions in higher plant events
  • Abstract Nitric oxide (NO) and hydrogen sulfide (H2S) are two molecules that share signaling properties in plant and animal cells. NO and H2S originate two families of derived molecules designated reactive nitrogen and sulfur species (RNS and RSS, respectively). These molecules are responsible for certain protein regulatory processes through posttranslational modifications (PTMs), being the most remarkable S-nitrosation and persulfidation, which affect the thiol group of cysteine residues. NO and H2S can also exert regulatory functions due to their interaction through the iron present in proteins that contain heme groups or iron-sulfur clusters, as reported mainly in animal cells. However, the available…
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  • Aneuploidy: An opportunity within single-cell RNA sequencing analysis
  • Abstract Single-cell sequencing data has transformed the understanding of biological heterogeneity. While many flavors of single-cell sequencing have been developed, single-cell RNA sequencing (scRNA-seq) is currently the most prolific form in published literature. Bioinformatic analysis of differential biology within the population of cells studied relies on inferences and grouping of cells due to the spotty nature of data within individual cell scRNA-seq gene counts. One biologically relevant variable is readily inferred from scRNA-seq gene count tables regardless of individual gene representation within single cells: aneuploidy. Since hundreds of genes are present on chromosome arms, high-quality inferences of aneuploidy can be made…
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  • Viral integration detection strategies and a technical update on Virus-Clip
  • Abstract Oncovirus infection is crucial in human malignancies. Certain oncoviruses can lead to structural variations in the human genome known as viral genomic integration, which can contribute to tumorigenesis. Existing viral integration detection tools differ in their underlying algorithms pinpointing different aspects or features of viral integration phenomenon. We discuss about major procedures in performing viral integration detection. More importantly, we provide a technical update on Virus-Clip to facilitate its usage on the latest human genome builds (hg19 and hg38) and the adoption of multi-thread mode for faster initial read alignment. By comparing the execution of Virus-Clip using single-thread and multi-thread…
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  • Identification of potential inhibitors for Sterol C-24 reductase of Leishmania donovani through virtual screening of natural compounds
  • Abstract Leishmaniasis is a vector-borne parasitic neglected tropical disease caused by a group of about 30 different species of the genus Leishmania. It is transmitted by the bite of female phlebotomies sand fly. Three main clinical manifestations of leishmaniasis include cutaneous, visceral, and mucocutaneous leishmaniasis. Visceral leishmaniasis (VL) caused by Leishmania donovani, is an infection of reticuloendothelial system and fatal if untreated. Cholesterol, a sterol that is prominent in the mammalian cell membranes whereas stigmasterol and ergosterol are more prevalent in plants, yeast, and protozoa, respectively. Ergosterols which is absent in human being, is an important constituent of parasite membrane. Sterol…
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  • Nanoscale interactions between the nicotinic acetylcholine receptor and cholesterol
  • Abstract Cholesterol is a major lipid in biological membranes. It not only plays a structural role but also modulates a wide range of functional properties of neurotransmitter and hormone receptors and ion channels. The membraneembedded segments of the paradigm neurotransmitter receptor for acetylcholine (nAChR) contain linear sequences of amino acids with the capacity to recognize cholesterol. These cholesterol consensus domains have been designated as “CARC” and its mirror sequence “CRAC”. CARC preferentially occurs in the exoplasmic-facing membrane leaflet, and CRAC, in the cytoplasmic-facing hemilayer. Both motifs are highly conserved among ion-channel and neurotransmitter receptor proteins in vertebrate nervous systems, where they…
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  • Characterization of endogenous nucleic acids that bind to NgAgo in Natronobacterium gregoryi sp2 cells
  • Abstract As nucleic acid-guided endonucleases, some prokaryotic Argonautes have been used as programmable nucleases. Natronobacterium gregoryi Argonaute (NgAgo) has also been proposed for gene editing, but this remains very controversial. Until now, the endogenous nucleic acids that bind to NgAgo in Natronobacterium gregoryi sp2 (N. gregoryi sp2) have not been characterized. We expressed the conserved PIWI domain of NgAgo and used it to induce anti-PIWI antibody. We also cultured the N. gregoryi sp2 strain and performed immunoprecipitation, chromatin immunoprecipitation (ChIP), and RNA immunoprecipitation (RIP) assays. The nucleic acids that endogenously bound NgAgo in N. gregoryi sp2 cells were sequenced and analyzed.…
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