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  • A Visual pH Indicator through Purple Cabbage Dye for Freshness Test of Venison
  • Abstract A visual pH indicator through purple cabbage dye is selected to test the freshness of venison. Chitosan and cassava starch of an equal weight were used to prepare the film-forming matrix of the indicator. The crystallization of natural purple cabbage dyes with a weight ratio of 5%, 10%, 20% and 40% were added to the matrix, respectively. The pH color test showed that the natural purple cabbage lyophilized powder with a weight ratio of 40% was the best for the pH indicator, which was used to test the freshness of venison stored at 4℃. The total bacterial count, volatile basic…
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  • Social Network Rumor Recognition Based on Enhanced Naive Bayes
  • Abstract In recent years, with the increasing popularity of social networks, rumors have become more common. At present, the solution to rumors in social networks is mainly through media censorship and manual reporting, but this method requires a lot of manpower and material resources, and the cost is relatively high. Therefore, research on the characteristics of rumors and automatic identification and classification of network message text is of great significance. This paper uses the Naive Bayes algorithm combined with Laplacian smoothing to identify rumors in social network texts. The first is to segment the text and remove the stop words after…
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  • A PageRank-Based WeChat User Impact Assessment Algorithm
  • Abstract In recent years, the mobile Internet has developed rapidly, and the network social platform has emerged as the times require, and more people make friends, chat and share dynamics through the network social platform. The network social platform is the virtual embodiment of the social network, each user represents a node in the directed graph of the social network. As the most popular online social platform in China, WeChat has developed rapidly in recent years. Large user groups, powerful mobile payment capabilities, and massive amounts of data have brought great influence to it. At present, the research on WeChat network…
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  • A Small Simulated Logistics Transfer Robot Car Structure Design
  • Abstract As a new product of the development of modern science and technology, the research and development of logistics robot has become the focus of social attention. Robot sorting and handling is the designated project of Jiangsu University Robot Competition. According to the requirements of the competition, this paper designs a kind of logistics robot trolley which can identify and grab materials according to a given path and transport them to a predetermined location. The mechanical structure design, driving motor selection and mechanical checking calculation of the car are mainly completed. According to the later experiments, the results show that the…
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  • Nanotherapeutics approaches to improve the efficacy of CAR-T cells in solid tumors
  • Abstract Adoptive cell therapy and Immune Checkpoint Blockade Inhibitors have recently revolutionized the field of oncology. However, these types of immunotherapeutic approaches have limited success in treating solid tumors. In particular, chimeric antigen receptor (CAR)-T cells efficacy is hampered by immunosuppressive signals in the tumor microenvironment (TME) and by a limited infiltration of re-infused T cells to the tumor site. The field of nanobiotechnology applied to oncology is also rapidly expanding. Nanoparticles-based delivery systems can be employed to modulate the activity of immune cells present in the TME enhancing the efficacy of CAR-T cells. Interestingly, nano-backpacks can be attached to CAR-T…
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  • KIFC1 overexpression promotes prostate cancer cell survival and proliferation in vitro by clustering of amplified centrosomes via interaction with Centrin 2
  • Abstract Mitotic kinesin KIFC1 plays critical roles in mitosis by regulating the spindle length, pole formation, and known for clustering extra centrosomes in cancer cells. Centrosome clustering is associated with the survival of cancer cells, but this phenomenon remains obscure in prostate cancer (PCa). The present study demonstrated that PCa cells showed centrosome amplification and clustering during interphase and mitosis, respectively. KIFC1 is highly expressed in PCa cells and tumor tissues of prostatic adenocarcinoma (PAC) patients. Up-regulation of KIFC1 facilitated the PCa cell survival in vitro by ensuring bipolar mitosis through clustering the multiple centrosomes, suggesting centrosome clustering could be a…
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  • Mechano-Sensing and shear stress-shielding by endothelial primary cilia: structure, composition, and function
  • Abstract Primary cilium is an antenna-like and non-motile structure protruding from the apical surface of most mammalian cells including endothelial cells lining the inner side of all the blood vessels in our body. Although it has been over a century since primary cilia were discovered, the investigation about their mechano-sensing and other roles in maintaining normal functions of cardiovascular system has just started in recent years. This focused review aims to give an update about the current literature for the role of endothelial primary cilia in blood flow mechano-sensing and shear stress-shielding. To do this, we first summarized the characteristic features…
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  • Effects of docosahexaenoic acid or arachidonic acid supplementation on gene expression and contractile force of rat cardiomyocytes in primary culture
  • Abstract While fatty acids play essential roles in the physiology of the myocardium, conventional culture media contain little lipid. We previously revealed that rat neonatal myocardium mainly contains docosahexaenoic (DHA), linoleic (LA), and arachidonic (AA) acids as polyunsaturated fatty acids (PUFAs), and these contents in cultured cardiomyocytes derived from fetal rats were markedly lower than those in the neonatal myocardium. In this study, we first assessed the effects of supplementation of DHA, LA, or AA on the fatty acid contents and the percentage change of contractile area in primarily cultured rat cardiomyocytes. Based on this assessment, we then evaluated the effects…
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  • Effects of lead (Pb)-induced oxidative stress on morphological and physio-biochemical properties of rice
  • Abstract

    In rice, high concentration of lead (Pb) can cause phyto-toxicity affecting several physiological functions. Cultivation of rice varieties that are resistant to Pb-induced oxidative stress is an important management strategy in Pb-contaminated soils. In the current study, we evaluated four different rice cultivars for their response to Pb-induced stress. Three japonica type cultivars X-Jigna, Ediget, and Furat, and one Indica type cultivar Amber 33 were grown in soil containing different Pb concentrations (0 mM, 0.6 mM, and 1.2 mM). The soil was treated with 0 mM or 0.6 mM or 1.2 mM Pb solution one month prior to rice seedling…

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  • TaVNS reduces inflammatory responses in a L-NAME-induced rat model of pre-eclampsia
  • Abstract Pre-eclampsia is characterized by an excessive maternal inflammatory response. The cholinergic anti-inflammatory pathway (CAP) has been shown as the efferent arm of a vagal reflex with the potential to limit inflammatory responses. Therefore, in this study, the CAP regulation through the nervous vagal stimulation (VNS) reduced the severity of NG-nitro-L-arginine methyl ester (L-NAME)-induced pre-eclampsia was determined in a rat model. Rats were given 125 mg/kg/day of L-NAME via subcutaneous injection on gestational day (GD) 10–16. In addition, the rats were treated by active or sham electrical stimulation once a day during GD 13–19. Systolic blood pressure (SBP), urinary albumin, and…
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