oncologieOpen Access


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About Journal

Oncologie is aimed to the publication of high quality original research articles, review papers, case report, etc. with an active interest in vivo or vitro study of cancer biology. Study relating to the pathology, diagnosis, and advanced treatment of all types of cancers, as well as research from any of the disciplines related to this field of interest. The journal has English and French bilingual publication.
The French Society of Oncology Surgery (SFCO), associoation francophone des soins oncologiques de support (AFSOS) and the French Federation of Medical Oncologists (FFOM) are affiliated with the journal Oncologie.Read More


    Acceptability of Elderly Cancer Patients and Tolerance to COVID-19 Vaccination in the Brittany Region
    L’acceptabilité du Patient Âgé Porteur de Cancer et la Tolérance à la Vaccination Anti-COVID-19 dans la Région Bretagne

    Oncologie, Vol.23, No.4, pp. 453-461, 2021, DOI:10.32604/oncologie.2021.019964
    Abstract Context: Since January 2021, vaccination for COVID-19 has been made possible in France for people aged 75 and over. Patients suffering from a cancer disease are part of a group at risk to develop severe complications to COVID-19. Method: The « Unité de coordination en Onco-Gériatrie région Bretagne » (the Brittany This work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Coordinating Unit in Onco-Geriatrics) has wished to set up an inquest about the acceptability and the tolerance to COVID-19 vaccination… More >


    Applications of CRISPR-Cas System in Tumor Biology

    Oncologie, Vol.23, No.4, pp. 463-492, 2021, DOI:10.32604/oncologie.2022.019415
    Abstract The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system, which is an RNA-guided nuclease system, plays an important role in the adaptive immune response of bacteria, and it is a rapidly developing gene editing technology. It has been widely used in a variety of cells, microorganisms, plants, and animals. This technique has helped to overcome the limitations of previous gene editing methods, and it has promoted the development of synthetic biology, genetics, and proteomics. The ability of the CRISPR-Cas system to modify the genetic components of a system has led to various practical applications, such as base editing, transcription regulation,… More >


    Synthesis, Pharmacological Evaluation, and In-Silico Studies of Thiophene Derivatives

    Oncologie, Vol.23, No.4, pp. 493-514, 2021, DOI:10.32604/oncologie.2021.018532
    Abstract The relevance of Retinoic acid receptor-related orphan receptors in cancer progression has sparked interest in developing multifunctional therapeutics. In the search for potentially active novel compounds with anticancer characteristics, the Gewald reaction was employed to develop different thiophene derivatives (8a–8i). Physicochemical and spectroanalytical investigations verified the molecular structures of the synthesized derivatives. Using an in vitro primary anticancer assay, NCI chose all of the synthesized molecules as prototypes and assessed their anticancer efficacy against a panel of various cancer cell lines representing nine distinct neoplasms. The compounds were found to have a wide range of anticancer activity. Following significant anticancer… More >


    The Current Status of Chlorin e6-Based Nanoscale Delivery Systems for Cancer Therapy

    Oncologie, Vol.23, No.4, pp. 515-531, 2021, DOI:10.32604/oncologie.2021.019856
    Abstract Improving the effectiveness of cancer treatment has become a central concern for the public. In recent years, in order to maximize the efficiency of cancer treatment, photodynamic therapy (PDT) and sonodynamic therapy (SDT) have received widespread attention. Chlorin e6 (Ce6) is a fluorescent dye with strong optical properties and excellent photoconversion efficiency under near-infrared light irradiation, which has been widely used in PDT in recent decades due to its superior antitumor ability. Of note, Ce6 can be used as a sonosensitizer for SDT, which generates large amounts of reactive oxygen species (ROS) for tumor treatment after ultrasound activation. These strategies… More >


    Predictive Value of p62 Protein in the Recurrence of Oral Squamous Cell Carcinoma

    Oncologie, Vol.23, No.4, pp. 533-546, 2021, DOI:10.32604/oncologie.2021.018705
    Abstract Background: Tumor recurrence is one of the major problems that affect the postoperative efficacy of oral squamous cell carcinoma (OSCC) treatment. Autophagy is known to have a dual-sided effect on tumors. However, studies on autophagy and prognosis are limited. The purpose of this study is to analyze the relationship between autophagy and OSCC recurrence. Materials and methods: 72 patients with OSCC were followed for 5 years after curative surgery. Tissue specimens from each patient were divided into tumor, normal, and marginal groups. Autophagy protein expression was assessed by western blotting and immunofluorescence. Statistical significance was evaluated using the chi-square test.… More >


    In vivo Effects of Aqueous Extract of Gongronema latifolium Benth on the Tumor Necrosis Factor-α, Transforming Growth Factor-β, and Hepatic Enzymes

    Oncologie, Vol.23, No.4, pp. 547-557, 2021, DOI:10.32604/oncologie.2021.019738
    Abstract Nonsteroidal anti-inflammatory drugs have a number of side effects. However, some medicinal herbs have anti-inflammatory properties with few side effects. This study aimed to determine the effect of the aqueous extract of Gongronema latifolium (AEGL) leaves on the level of tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in rabbits. Enzyme-linked immunosorbent assay (ELISA) was performed to determine the effect of the AEGL on the activities of pro-inflammatory cytokine (TNFα), and regulatory cytokine (TGF-β) in rabbits. Also, a colorimetric method was performed to evaluate the levels of AST and ALT. Overall, the weight… More >


    A Retrospective Analysis of 94 Patients with Hemophagocytic Lymphohistiocytosis of Unknown Etiology from a Single Center

    Oncologie, Vol.23, No.4, pp. 559-567, 2021, DOI:10.32604/oncologie.2021.018647
    Abstract Despite extensive work-ups, some patients have been diagnosed with hemophagocytic lymphohistiocytosis (HLH) of unknown etiology. For HLH of unknown etiology, to investigate the clinical features and the factors that may affect the prognosis, we retrospectively reviewed the medical records of 94 patients hospitalized from January 2014 to December 2019. Survival times were evaluated until April 2020. For the 94 patients, the underlying causes of their diseases remained unclear at the end of the follow-up period, and the 1-, 3-, and 6-month survival rates, and the overall survival (OS) rates were 86.2%, 78.7%, 73.4%, and 70.2%, respectively. The multivariate analysis showed… More >


    Epigenetics of Sirtuins: Relevance to Hepatocellular Carcinoma

    Oncologie, Vol.23, No.4, pp. 569-588, 2021, DOI:10.32604/oncologie.2021.018869
    Abstract Sirtuins (SIRTs), members of the enzyme family found in yeast cells, are related to silent information regulator (SIR) 2 homologous to its gene family. SIRTs play an important role in many physiological functions from overexpression of gene silencing at the molecular level to the expression of related proteins and RNA to apoptosis. Studies have indicated that SIRTs may be related to the occurrence, development, and metastasis of cancer. However, the current mechanism of action of SIRTs in various diseases and the principle of molecular biology are not fully understood. Therefore, the present article discusses the main regulatory role and function… More >


    Circular RNA hsa_circ_0016863 Regulates the Proliferation, Migration, Invasion and Apoptosis of Hepatocellular Carcinoma

    Oncologie, Vol.23, No.4, pp. 589-601, 2021, DOI:10.32604/oncologie.2021.018713
    Abstract Background: Although there has been a part of research that the expression of circular RNAs (circRNAs) is bound up with the occurrence, development and prognosis of multiple tumors, what roles circRNAs have in hepatocellular carcinoma (HCC) remain to be explored. Methods: Hsa_circ_0016863 showed a trend of high expression in HCC tissues by Microarray GSE97332. The expression of hsa_circ_0016863 in HCC and adjacent non-cancerous tissues was detected by qRT-PCR. The role of hsa_circ_0016863 in HCC was investigated by colony formation assay, cell proliferation assay, Transwell assay and flow cytometry. Results: Hsa_circ_0016863 exhibited a trend of high expression in HCC. Cell experiments… More >


    A Rare Case of Atraumatic Splenic Rupture Due to Metastatic Hepatocellular Carcinoma

    Oncologie, Vol.23, No.4, pp. 603-608, 2021, DOI: 10.32604/oncologie.2021.019519
    Abstract Metastatic spread of hepatocellular carcinoma (HCC) to the spleen is uncommon, only occurring in approximately 1% of cases. Atraumatic splenic rupture due to HCC metastasis is extremely rare and affects patient prognosis, clinical management, and mortality. We report a case of a 65-year-old man with a history of chronic hepatitis B infection who presented with left-sided abdominal pain and fatigue. Clinical examination showed acute anemia with elevated levels of serum alpha-fetoprotein (AFP) and protein induced by vitamin K absence (PIVKA-II). On ultrasound and computed tomography imaging, hemoperitoneum caused by a ruptured splenic tumor was revealed. In addition to multiple hepatic… More >



    A Narrative Review: Classification of Pap Smear Cell Image for Cervical Cancer Diagnosis

    Oncologie, Vol.22, No.2, pp. 53-63, 2020, DOI:10.32604/oncologie.2020.013660
    Abstract Cervical cancer develops as cells transformation in the cervix of a female that connects the uterus to the vagina. This cancer may impact the columnal epithelial cells of the cervix and therefore can be expanded to the lymphatic and circulatory system (metastasize), sometimes the kidneys, liver, prostate, vagina, and rectum. Many of the cervical cancer patients survived by taking early prevention by undergoing a Pap Smear Test. However, the result of the test usually takes a few weeks which is extremely time-consuming especially at the government hospital. The purpose of this research was to study the detection and classification method… More >


    Analysis of the Effects of Different Surgical Procedures for the Treatment of Thyroid Cancer on the Expression Levels of IL-17, IL-35, and SIL-2R and the Prognostic Factors

    Oncologie, Vol.22, No.1, pp. 43-51, 2020, DOI:10.32604/oncologie.2020.012445
    Abstract To analyze the effects of different surgical procedures for the treatment of thyroid cancer on the expression levels of serum interleukin-17 (IL-17), IL-35, soluble interleukin-2 receptor (SIL-2R), and the prognostic factors. Seventy-eight patients with differentiated thyroid cancer were selected and grouped as control group (CG) (n = 39, underwent subtotal thyroidectomy) and observation group (OG) (n = 39, underwent total thyroidectomy). The serum IL-17, IL-35, and SIL- 2R expression levels; the incidence of complications; and the differentiated thyroid carcinoma (DTC) relapse rate were compared between the two groups. The serum IL-17 and SIL-2R levels were lower in the OG than… More >


    Diagnosis of Lung Cancer Based on Plasma Metabolomics Combined with Serum Markers

    Oncologie, Vol.22, No.2, pp. 75-82, 2020, DOI:10.32604/oncologie.2020.012376
    Abstract Predicting the onset and metastasis of early tumor is the primary means of improving lung cancer prognosis. The purpose of this study was to identify the ability of plasma metabolomics combined with blood markers to establish benign lung disease versus lung cancer regression models. Blood samples were collected from 174 lung cancer patients, 350 benign lung disease patients and 100 healthy volunteers and the metabolites were analyzed by mass spectrometry. The target metabolites consisted of 23 amino acids, 26 acylcarnitines and 45 conventional blood markers. A regression analysis model was established based on 12 metabolites and five blood markers selected… More >


    Expression Changes, Prognostic Analysis and Risk Factors of miR-625-3p and miR-449a in Osteosarcoma Patients after Surgery

    Oncologie, Vol.22, No.1, pp. 23-33, 2020, DOI:10.32604/oncologie.2020.012493
    Abstract The expression changes of miR-625-3p and miR-449a in osteosarcoma patients after surgery is the critical study in this paper. Analysis of their prognosis and risk factors can be helpful in understanding the prognostic value for clinical purposes. Fifty-eight patients with osteosarcoma diagnosed in our hospital were considered as the research group (RG), and 52 health subjects at the same time were collected as the control group (CG). Fluorescence quantitative PCR (RTPCR) was employed to test the expression levels of miR-625-3p and miR-449a in the serum of subjects in both groups before surgery and patients in the RG after surgery. The… More >


    Sinomenium Inhibits the Viability of Hepatoma Carcinoma Cells through Activating IFNA2

    Oncologie, Vol.22, No.1, pp. 1-12, 2020, DOI:10.32604/oncologie.2020.012436
    Abstract Hepatocellular carcinoma (HCC) ranks the sixth place of most common cancers. Meanwhile, it is the tertiary mortality cause of cancer. There is no effective therapeutic method to prevent and treat the liver cancer. Sinomenine is a kind of Chinese traditional medicine herbal, it is reported that it can inhibit the viability of several cancer cells. The study is to explore whether sinomenine is also able to inhibit the cell viability of HCC and its potential mechanism. The IC50 of sinomenine in BEL-7402 cells was 5.351 mmol/L, and the IC50 of sinomenine in SMMC-7721 cells was 6.204 mmol/L. The gene expression… More >


    Diagnostic Performance of Serum miR-586 and miR-493 in Patients with Osteosarcoma

    Oncologie, Vol.22, No.1, pp. 35-42, 2020, DOI:10.32604/oncologie.2020.012485
    Abstract This study aimed to explore the expression and diagnostic performance of miR-586 and miR-493 in patients with osteosarcoma. We enrolled 63 patients with osteosarcoma treated between May 2016 and May 2019 as the experimental group and 55 healthy volunteers who underwent physical examination during the same period as the control group. We detected miR-586 and miR-493 expression in serum, normal bone tissue, and tumor samples. We also evaluated the relationship between clinical indicators and the miR-586 and miR-493 expression levels. The correlation between the serum and osteosarcoma tissue expression of miR-586 and miR-493 was examined by Pearson analysis. Furthermore, the… More >

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