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Molecular & Cellular Biomechanics

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About Journal

The field of biomechanics concerns with motion, deformation, and forces in biological systems. With the explosive progress in molecular biology, genomic engineering, bioimaging, and nanotechnology, there will be an ever-increasing generation of knowledge and information concerning the mechanobiology of genes, proteins, cells, tissues, and organs. Such information will bring new diagnostic tools, new therapeutic approaches, and new knowledge on ourselves and our interactions with our environment. It becomes apparent that biomechanics focusing on molecules, cells as well as tissues and organs is an important aspect of modern biomedical sciences. The aims of this journal are to facilitate the studies of the mechanics of biomolecules (including proteins, genes, cytoskeletons, etc.), cells (and their interactions with extracellular matrix), tissues and organs, the development of relevant advanced mathematical methods, and the discovery of biological secrets. As science concerns only with relative truth, we seek ideas that are state-of-the-art, which may be controversial, but stimulate and promote new ideas, new techniques, and new applications. This journal will encourage the exchange of ideas that may be seminal, or hold promise to stimulate others to new findings.Read More


    Nuclear Stress-Strain State over Micropillars: A Mechanical In silico Study

    Molecular & Cellular Biomechanics, Vol.19, No.1, pp. 1-16, 2022, DOI:10.32604/mcb.2022.018958
    Abstract Cells adapt to their environment and stimuli of different origin. During confined migration through sub-cellular and sub-nuclear pores, they can undergo large strains and the nucleus, the most voluminous and the stiffest organelle, plays a critical role. Recently, patterned microfluidic devices have been employed to analyze the cell mechanical behavior and the nucleus self-deformations. In this paper, we present an in silico model to simulate the interactions between the cell and the underneath microstructured substrate under the effect of the sole gravity. The model lays on mechanical features only and it has the potential to assess the contribution of the… More >


    Lung Nodule Detection Based on YOLOv3 Deep Learning with Limited Datasets

    Molecular & Cellular Biomechanics, Vol.19, No.1, pp. 17-28, 2022, DOI:10.32604/mcb.2022.018318
    Abstract The early symptom of lung tumor is always appeared as nodule on CT scans, among which 30% to 40% are malignant according to statistics studies. Therefore, early detection and classification of lung nodules are crucial to the treatment of lung cancer. With the increasing prevalence of lung cancer, large amount of CT images waiting for diagnosis are huge burdens to doctors who may missed or false detect abnormalities due to fatigue. Methods: In this study, we propose a novel lung nodule detection method based on YOLOv3 deep learning algorithm with only one preprocessing step is needed. In order to overcome… More >


    Classification of Leukemia and Leukemoid Using VGG-16 Convolutional Neural Network Architecture

    Molecular & Cellular Biomechanics, Vol.19, No.1, pp. 29-40, 2022, DOI:10.32604/mcb.2022.016966
    Abstract Leukemoid reaction like leukemia indicates noticeable increased count of WBCs (White Blood Cells) but the cause of it is due to severe inflammation or infections in other body regions. In automatic diagnosis in classifying leukemia and leukemoid reactions, ALL IDB2 (Acute Lymphoblastic Leukemia-Image Data Base) dataset has been used which comprises 110 training images of blast cells and healthy cells. This paper aimed at an automatic process to distinguish leukemia and leukemoid reactions from blood smear images using Machine Learning. Initially, automatic detection and counting of WBC is done to identify leukocytosis and then an automatic detection of WBC blasts… More >


    Comparative Study on Biomechanics of Two Legs in the Action of Single-Leg Landing in Men’s Badminton

    Molecular & Cellular Biomechanics, Vol.19, No.1, pp. 41-50, 2022, DOI:10.32604/mcb.2022.017044
    Abstract This study aims to analyze the biomechanical difference between the two legs of male badminton players when they land on one leg, thereby providing some guidance for preventing sports injury. Ten male badminton players were selected as the subjects. They did the single-leg landing movement successfully three times. The kinematic data were obtained by the Vicon infrared high-speed motion capture system. The kinetic data were obtained by the KISTLER three-dimensional forcing measuring platform. The data were processed and analyzed. The center of gravity of the right leg on the X and Y axes were 0.25 ± 0.05 and 0.21 ± 0.04 m, respectively, which were… More >


    Effect of Resistance Training and Spirulina platensis on Expression of IL-6, Gp130 Cytokines, JAK-STAT Signaling in Male Rats Skeletal Muscle

    Molecular & Cellular Biomechanics, Vol.19, No.1, pp. 51-59, 2022, DOI:10.32604/mcb.2022.018345
    Abstract The effect of resistance training and a herbal supplement on muscular signaling pathways are limited. We investigated the expression of IL-6, Gp130, JAK and STAT after resistance training, and Spirulina platensis supplementation in animal muscle. Thirty-two male Sprague Dawley rats (weight: 290 ± 20 g, and 9 weeks of age) were divided into four groups: control (CO; n = 8), Spirulina platensis supplementation (SP; n = 8), resistance exercise (RE; n = 8), and Spirulina platensis + resistance exercise (SP + RE; n = 8). The resistance exercise group trained five sessions each week for eight weeks. Spirulina 200 mg… More >


    Kinematic and Dynamic Characteristics of Pulsating Flow in 180o Tube

    Molecular & Cellular Biomechanics, Vol.17, No.1, pp. 19-24, 2020, DOI:10.32604/mcb.2019.07817
    Abstract Kinematic and dynamic characteristics of pulsating flow in a model of human aortic arch are obtained by a computational analysis. Three-dimensional flow processes are summarized by pressure distributions on the symmetric plane together with velocity and pressure contours on a few cross sections for systolic acceleration and deceleration. Without considering the effects of aortic tapering and the carotid arteries, the development of tubular boundary layer with centrifugal forces and pulsation are also analyzed for flow separation and backflow during systolic deceleration. More >


    A Retrospective Respiratory Gating System Based on Epipolar Consistency Conditions

    Molecular & Cellular Biomechanics, Vol.17, No.1, pp. 41-48, 2020, DOI:10.32604/mcb.2019.07383
    Abstract Motion artifacts of in vivo imaging, due to rapid respiration rate and respiration displacements of the mice while free-breathing, is a major challenge in micro computed tomography(micro-CT). The respiratory gating is often served for either projective images acquisition or per projection qualification, so as to eliminate the artifacts brought by in vivo motion. In this paper, we propose a novel respiratory gating method, which firstly divides one rotation cycle into a number of segments, and extracts the respiratory signal from the projective image series of current segment by the value of the epipolar consistency conditions (ECC), then in terms of… More >


    A Study on the Finite Element Model for Head Injury in Facial Collision Accident

    Molecular & Cellular Biomechanics, Vol.17, No.1, pp. 49-62, 2020, DOI:10.32604/mcb.2019.07534
    Abstract In order to predict and evaluate injury mechanism and biomechanical response of the facial impact on head injury in a crash accident. With the combined modern medical imaging technologies, namely computed tomography (CT) and magnetic resonance imaging (MRI), both geometric and finite element (FE) models for human head-neck with detailed cranio-facial structure were developed. The cadaveric head impact tests were conducted to validate the headneck finite element model. The intracranial pressure, skull dynamic response and skull-brain relative displacement of the whole head-neck model were compared with experimental data. Nine typical cases of facial traffic accidents were simulated, with the individual… More >


    New Concept in Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA)

    Molecular & Cellular Biomechanics, Vol.17, No.1, pp. 25-31, 2020, DOI:10.32604/mcb.2019.07310
    Abstract The world-wide impact of traumatic injury and associated hemorrhage on human health and well-being is significant. Methods to manage bleeding from sites within the torso, referred to as non-compressible torso hemorrhage (NCTH), remain largely limited to the use of conventional operative techniques. The overall mortality rate of patients with NCTH is approximately 50%. Studies from the wars in Afghanistan and Iraq have suggested that up to 80% of potentially survivable patients die as a result of uncontrolled exsanguinating hemorrhage. The commercially available resuscitative endovascular balloon occlusion of the aorta (REBOA) is a percutaneous device for the rapid control of torso… More >


    Multifrequency Microwave Imaging for Brain Stroke Detection

    Molecular & Cellular Biomechanics, Vol.17, No.1, pp. 33-40, 2020, DOI:10.32604/mcb.2019.07165
    Abstract CT and MRI are often used in the diagnosis and monitoring of stroke. However, they are expensive, time-consuming, produce ionizing radiation (CT), and not suitable for continuous monitoring stroke. Microwave imaging (MI) has been extensively investigated for identifying several types of human organs, including breast, brain, lung, liver, and gastric. The authors recently developed a holographic microwave imaging (HMI) algorithm for biological object detection. However, this method has difficulty in providing accurate information on embedded small inclusions. This paper describes the feasibility of the use of a multifrequency HMI algorithm for brain stroke detection. A numerical system, including HMI data… More >


    On the Onset of Cracks in Arteries1

    Molecular & Cellular Biomechanics, Vol.17, No.1, pp. 1-17, 2020, DOI:10.32604/mcb.2019.07606
    Abstract We present a theoretical approach to study the onset of failure localization into cracks in arterial wall. The arterial wall is a soft composite comprising hydrated ground matrix of proteoglycans reinforced by spatially dispersed elastin and collagen fibers. As any material, the arterial tissue cannot accumulate and dissipate strain energy beyond a critical value. This critical value is enforced in the constitutive theory via energy limiters. The limiters automatically bound reachable stresses and allow examining the mathematical condition of strong ellipticity. Loss of the strong ellipticity physically means inability of material to propagate superimposed waves. The waves cannot propagate because… More >

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