biocellOpen Access

BIOCELL

ISSN:0327-9545(print)
ISSN:1667-5746(online)
Publication Frequency:Bimonthly (Regular issues of BIOCELL will be published monthly starting from 2022.)

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Table of Content

About Journal

BIOCELL is an international, peer-reviewed, open access journal on molecular and cellular biosciences. The journal welcomes high quality original research articles, review papers, communications, perspectives, commentaries, etc. Topics of interests include but are not limited to: Cellular Biochemistry, Structural & Molecular Biology, Cellular/Molecular Biology, Immunology, Pathology & Neurobiology, Cell Signaling, Regenerative Biology & Stem Cells, Cancer Biology, RNA Biology, Genomics, Transcriptomics, Proteomics & Metabolomics, Plant Molecular & Cellular Biology.Read More

  • VIEWPOINT

    Crosslinking-mediated activation of the FcεRI: Does it need antigen for success?

    BIOCELL, Vol.46, No.5, pp. 1125-1129, 2022, DOI:10.32604/biocell.2022.018513
    Abstract Mast cells (MCs), hematopoietic cells of the myeloid lineage, are well-known for their pro-inflammatory nature contributing to the development of various allergic and autoimmune diseases. One of the characteristic receptors on MCs, the high-affinity receptor for IgE (FcεRI), is activated in its IgE-bound state via binding and crosslinking by polyvalent antigen. This results in its phosphorylation by the SRC family kinase LYN, initiating differential signaling pathways, eventually triggering immunological effector functions, such as degranulation and cytokine production. Few publications have reported on FcεRI-dependent but antigen-independent MC activation by antibody-mediated crosslinking of membrane molecules (e.g., transmembrane proteins and glycosphingolipids) that are… More >

  • REVIEW

    ER exit pathways and the control of proteostasis: Crucial role of the UPR, COPII, and ER-phagy in the secretory pathway

    BIOCELL, Vol.46, No.5, pp. 1131-1137, 2022, DOI:10.32604/biocell.2022.018638
    Abstract The endoplasmic reticulum (ER) is the site of entry of all proteins that function in the secretory pathway including the extracellular environment. Because it controls the folding of newly synthesized secretory proteins, the ER is indispensable for the maintenance of proteostasis in the secretory pathway. Within the ER and, in part, in post-ER compartments, the quality control of protein folding is under the regulation of the unfolded protein response (UPR) pathways. The UPR strategy is to enhance protein folding, increase the ER degradation pathway of misfolded proteins, and allow the exit from the ER of only correctly folded proteins. The… More >

  • REVIEW

    Use of Impella cardiac axial flow pump for cardiogenic shock (A newer alternative)–How good is the evidence?

    BIOCELL, Vol.46, No.5, pp. 1139-1150, 2022, DOI:10.32604/biocell.2022.016833
    (This article belongs to this Special Issue: Cellular Biomechanics in Health and Diseases)
    Abstract The adverse outcomes of a ventricular heart failure (left, right or biventricular) caused by cardiogenic shock are aggravated by lung oedema and organ mal perfusion. Despite advances in medical sciences, revascularisation and mechanical hemodynamic support have proved ineffective in reducing the mortality rate in such patients. A thorough study of the data available about cardio-vascular diseases reveals that the application of conventional methods of treatment are least helpful to practically restore normal functions of heart when it experiences end-stage systolic ventricular failure. Thus, to overcome the challenges and find alternatives to address this issue, percutaneous ventricular support devices/machines were designed… More >

  • VIEWPOINT

    Implant surface features as key role on cell behavior

    BIOCELL, Vol.46, No.5, pp. 1151-1156, 2022, DOI:10.32604/biocell.2022.018026
    Abstract It has been recognized that physical and chemical properties of biomaterial surfaces mediate the quality of extracellular matrix (ECM) that may affect cell behaviors. In nature, ECM is a heterogeneous three-dimensional superstructure formed by three major components, glycosaminoglycan, glycoconjugate, and protein, that anchors cellular compartments in tissues and regulates the function and the behavior of cells. Changes in the biointerface alter the quality of ECM and morphology through cell surface receptors, which, in turn, enable it to trigger specific cell signaling and different cellular responses. In fact, a number of strategies have been used to improve the functionality of surfaces… More >

  • VIEWPOINT

    Synergy of single-cell sequencing analyses and in vivo lineage-tracing approaches: A new opportunity for stem cell biology

    BIOCELL, Vol.46, No.5, pp. 1157-1162, 2022, DOI:10.32604/biocell.2022.018960
    (This article belongs to this Special Issue: Single Cell Analysis: Technology and Application)
    Abstract Single-cell sequencing technologies have rapidly progressed in recent years, and been applied to characterize stem cells in a number of organs. Somatic (postnatal) stem cells are generally identified using combinations of cell surface markers and transcription factors. However, it has been challenging to define micro-heterogeneity within “stem cell” populations, each of which stands at a different level of differentiation. As stem cells become defined at a single-cell level, their differentiation path becomes clearly defined. Here, this viewpoint discusses the potential synergy of single-cell sequencing analyses with in vivo lineage-tracing approaches, with an emphasis on practical considerations in stem cell biology. More >

  • ARTICLE

    Secretome-microRNA and anti-proliferative APRO family proteins as cancer prevention and stem cell research strategies

    BIOCELL, Vol.46, No.5, pp. 1163-1167, 2022, DOI:10.32604/biocell.2022.018177
    (This article belongs to this Special Issue: Mesenchymal Stem Cells, Secretome and Biomaterials: Regenerative Medicine Application)
    Abstract Stemness of cancer cells contains limitless self-renewal proliferation. For the purpose of proliferation, secretome might exert its effects via the paracrine signaling. Specific microRNAs enclosed in the secretome of cancer stem cells could regulate the expression of anti-proliferative APRO family proteins. The biological functions of APRO family proteins seems to be quite intricate, however, which might be a key modulator of microRNAs, then could regulate the proliferation of cancer cells. In addition to affecting proliferation/differentiation during cellular development, APRO family proteins might also play an imperious role on keeping homeostasis in healthy stem cells under a physiological condition. Therefore, relationship… More >

  • ARTICLE

    Mesenchymal stem cell-derived exosome: The likely game-changer in stem cell research

    BIOCELL, Vol.46, No.5, pp. 1169-1172, 2022, DOI:10.32604/biocell.2022.018470
    (This article belongs to this Special Issue: Mesenchymal Stem Cells, Secretome and Biomaterials: Regenerative Medicine Application)
    Abstract Stem cell research is a promising area of transplantation and regenerative medicine with tremendous potential for improving the clinical treatment and diagnostic options across a variety of conditions and enhancing understanding of human development. Over the past few decades, mesenchymal stem cell (MSCs) studies have exponentially increased with a promising outcome. However, regardless of the huge investment and the research attention given to stem cell research, FDA approval for clinical use is still lacking. Amid the challenges confronting stem cell research as a cell-based product, there appears to be evidence of superior effect and heightened potential success in its expressed… More >

  • VIEWPOINT

    Therapeutic mechanisms and routes of delivery of mesenchymal stem cells in veterinary medicine: A point of view

    BIOCELL, Vol.46, No.5, pp. 1173-1176, 2022, DOI:10.32604/biocell.2022.018637
    (This article belongs to this Special Issue: Mesenchymal Stem Cells, Secretome and Biomaterials: Regenerative Medicine Application)
    Abstract Mesenchymal stem cells (MSCs) represent an important tool in veterinary regenerative medicine due to their ability to home to injury sites and secrete molecules that regulate niches into regenerative microenvironments. Successful cell therapy depends on many factors, including choice of administration route and application of understanding of cell potency and their therapeutic mechanisms. In this point of view, the authors leverage the tumultuous history of the field to demonstrate the need for clinicians to continually update themselves as new discoveries are made in order to avoid misalignments in the future, especially regarding administration routes and dose frequency, as well as… More >

  • VIEWPOINT

    From organ-on-a-chip towards body-on-a-chip

    BIOCELL, Vol.46, No.5, pp. 1177-1180, 2022, DOI:10.32604/biocell.2022.019055
    Abstract Organ-on-a-chip technology aims to reproduce the key physiological features of human organs and tissues, even complex actions of multi-organ interaction. While organ-on-a-chips at single-organ level has made notable achievement during the last decade, multi-organ-on-a-chips, which manifests unique advantages, has started gathering attention only recently. In this viewpoint, we discuss the current status of organ-on-a-chip technology, with a specific emphasis on multi-organ-on-a-chip. Key technological advances contributing to the maturation of the field, and challenges that need to be addressed before wider adoption in relevant fields are discussed. We will share our perspectives on how the multi-organ-on-a-chip can improve the drug development… More >

  • ARTICLE

    Dihydropyrimidinase like 3 as a novel target of wild type p53 suppresses MAPK pathway in response to hypoxia

    BIOCELL, Vol.46, No.5, pp. 1181-1188, 2022, DOI:10.32604/biocell.2022.016148
    (This article belongs to this Special Issue: Cellular Biomechanics in Health and Diseases)
    Abstract Endometrial cancer remains to be a major type of malignancy in threatening female life. Molecular insights in advancing our understanding of endometrial tumorigenesis are much needed. We here report that a less-studied protein Dihydropyrimidinase like 3 (DPYSL3) is a potent tumor suppressor. DPYSL3 is uniquely regulated by wild type p53 (wtp53), and its expression is at the highest level when cells carry wtp53 and are exposed to hypoxia. We reveal that wtp53 can bind DPYSL3 promoter to enhance DPYSL3 expression and in turn, the elevated DPYSL3 can restrain cancer cell proliferation and invasion in vitro and in vivo. Importantly, we… More >

  • ARTICLE

    KIF18A is a potential prognostic factor and promotes tumor progression in oral tongue squamous cell carcinoma

    BIOCELL, Vol.46, No.5, pp. 1189-1196, 2022, DOI:10.32604/biocell.2022.018249
    (This article belongs to this Special Issue: Cellular Biomechanics in Health and Diseases)
    Abstract The kinesin family member 18A protein was dysregulated in several human cancers and involved in cancer progression. However, the significance in oral tongue squamous cell carcinoma (OTSCC) has not been studied. The present study was intended to explore the functions of KIF18A in oral tongue squamous cell carcinoma. The immunohistochemistry (IHC) assay was performed to assess the relationships between the KIF18A protein expression level and clinical-pathological features of the patients. The biological functions of KIF18A in OTSCC cells were investigated by the experiments in vitro and in vivo. Based on immunohistochemistry, we found that KIF18A was correlated with the clinical-pathological… More >

  • ARTICLE

    Human β-defensin 2 enhances IL-1β production and pyroptosis through P2X7-mediated NLRP3 expression in macrophages

    BIOCELL, Vol.46, No.5, pp. 1197-1207, 2022, DOI:10.32604/biocell.2022.016607
    (This article belongs to this Special Issue: Cellular Biomechanics in Health and Diseases)
    Abstract Periodontal disease is the leading cause of tooth loss, which is also a high-risk factor for other diseases including oral cancer and cardiovascular disease. Periodontitis is one of the most common type of periodontal diseases. Interleukin-1β (IL-1β) plays a key role in the pathogenesis of periodontitis. However, the mechanism how IL-1β is produced during periodontitis is still unclear. In the present study, we found that human β-defensin 2 (hBD2) enhances IL-1β production through an LPS-primed human acute monocytic leukemia (THP-1) macrophage model. Inhibition of P2X purinoceptor 7 (P2X7) reduced hBD2-enhanced IL-1β production. Incubation of LPS-primed THP-1 macrophages with potassium chloride… More >

  • VIEWPOINT

    ISG15 and ISGylation: Emergence in the cytoskeleton dynamic and tumor microenvironment

    BIOCELL, Vol.46, No.5, pp. 1209-1213, 2022, DOI:10.32604/biocell.2022.018136
    (This article belongs to this Special Issue: Tumor Microenvironment and Cytoskeletal Dynamics)
    Abstract Cytoskeletal remodeling affects the shape, adhesion, and motility of cells. Cytoskeletal dynamics are modulated by matrix proteins, integrins, and several cytokines in the tumor microenvironment. In this scenario, signaling is activated by integrins and interferons, which can induce ISG15 gene expression. This gene encodes a ubiquitin-like protein that functions as a protein modifier via the ISGylation system. Furthermore, non-conjugated ISG15 acts as a cytokine-like protein. In this viewpoint, the interplay between free ISG15, protein ISGylation, and cytoskeletal dynamics in the tumor microenvironment is discussed. More >

  • ARTICLE

    Prognostic tumor microenvironment gene and the relationship with immune infiltration characteristics in metastatic breast cancer

    BIOCELL, Vol.46, No.5, pp. 1215-1243, 2022, DOI:10.32604/biocell.2022.018221
    (This article belongs to this Special Issue: Tumor Microenvironment and Cytoskeletal Dynamics)
    Abstract The aim of this study was to reveal genes associated with breast cancer metastasis, to investigate their intrinsic relationship with immune cell infiltration in the tumor microenvironment, and to screen for prognostic biomarkers. Gene expression data of breast cancer patients and their metastases were downloaded from the GEO, TCGA database. R language package was used to screen for differentially expressed genes, enrichment analysis of genes, PPI network construction, and also to elucidate key genes for diagnostic and prognostic survival. Spearman’s r correlation was used to analyze the correlation between key genes and infiltrating immune cells. We screened 25 hub genes,… More >

  • ARTICLE

    Molecular mechanisms of Tanshinone IIA in Hepatocellular carcinoma therapy via WGCNA-based network pharmacology analysis

    BIOCELL, Vol.46, No.5, pp. 1245-1259, 2022, DOI:10.32604/biocell.2022.018117
    Abstract Hepatocellular carcinoma (HCC) is a worldwide malignant tumor that caused irreversible consequences. Tanshinone IIA has been shown to play a notable role in HCC treatment. However, the potential targets and associating mechanism of Tanshinone IIA against HCC remain unknown. We first screened out 105 overlapping genes by integrating the predicted targets of Tanshinone IIA from multiple databases and the differentially expressed genes of HCC from the Cancer Genome Atlas (TCGA) database. Then, we performed weighted gene co-expression network analysis (WGCNA) using the RNA-seq profiles of overlapping genes and HCC-related clinical information. 23 genes related to clinical tumor grade in the… More >

  • ARTICLE

    A novel prognostic target-gene signature and nomogram based on an integrated bioinformatics analysis in hepatocellular carcinoma

    BIOCELL, Vol.46, No.5, pp. 1261-1288, 2022, DOI:10.32604/biocell.2022.018427
    Abstract There is currently no effective solution to the problem of poor prognosis and recurrence of HCC. The technology of immunotherapy and prognosis of genetic material has made continuous progress in recent years. In the study, a 5-gene signature was established for the prognosis of HCC through biological information, and the immune infiltration of HCC patients was studied. After studied HCC patients’ immune infiltration, the paper screened the differential target genes of miR-126-3p in HCC downloaded from TCGA database, and uses WGCNA method to select the modular genes highly relevant to M2 macrophage. Then we use LASSO and COX regression analysis… More >

  • ARTICLE

    Downregulation of hsa_circ_0002198 inhibits keloid fibroblast activities in vitro by reducing NLRP3 inflammasome activity

    BIOCELL, Vol.46, No.5, pp. 1289-1297, 2022, DOI:10.32604/biocell.2022.016726
    Abstract The levels of hsa circular RNA_0002198 (hsa_circ_0002198) have been found to be significantly upregulated in keloid dermal fibroblasts. However, the functional role of hsa_circ_0002198 in keloid fibroblasts and the underlying molecular mechanism for its effects have not been reported. In this study, the levels of hsa_circ_0002198 and nucleotide-binding and oligomerization domain, leucine rich repeat and pyrin domain containing 3 (NLRP3) expression in keloid scar tissues and adjacent normal skin tissues were determined by quantitative real-time PCR and western blotting, respectively. In vitro models of keloid tissue were created by culturing primary keloid fibroblasts obtained from patients. A series of functional… More >

  • ARTICLE

    Pseudogene HMGN2P46 as a microRNA sponge to regulate HMGN2 expression via competing for miR-590-3p in severe acute pancreatitis

    BIOCELL, Vol.46, No.5, pp. 1299-1308, 2022, DOI:10.32604/biocell.2022.017217
    Abstract HMGN2 have functions in inflammatory response. However, the role of HMGN2 in severe acute pancreatitis (SAP) remains unclear. Here, our study was to discuss the role and regulatory mechanism ofHMGN2 in SAP. In this study, the SAP cell model of AR42J was used to study the function and mechanism of HMGN2 in SAP. The protein expression in cells and serums were examined by western blot and ELISA assay. qPCR was used to test the transcriptional RNA level. Cell viability were examined by MTT assay. Luciferase assay was used to evaluate the interaction between gene and gene. Our results showed that… More >

  • ARTICLE

    miR-181b promotes the oncogenesis of renal cell carcinoma by targeting TIMP3

    BIOCELL, Vol.46, No.5, pp. 1309-1317, 2022, DOI:10.32604/biocell.2022.018167
    (This article belongs to this Special Issue: Noncoding RNAs & Associated Human Diseases)
    Abstract Renal cell carcinoma (RCC) has a poor prognosis due to limited diagnosis and treatment. Thus, it is necessary to find novel prognostic biomarkers and therapeutic targets. The aberrant expression of microRNAs plays an important role in RCC oncogenesis. Tissue inhibitors of metalloproteinase 3 (TIMP3) acts as a downstream target of miR-181b. The aim of this study was to understand the role and molecular mechanism of miR-181b in RCC oncogenesis. The results showed that miR-181b expression was significantly higher in RCC tumour tissues, especially in those with significant invasion or metastasis. miR-181b overexpression promoted proliferation and migration of the RCC cell… More >

  • ARTICLE

    miRNA-148b-3p targeting SOCS3 inhibits macrophage M2 polarization by JAK2/STAT3 pathway in immune thrombocytopenia

    BIOCELL, Vol.46, No.5, pp. 1319-1328, 2022, DOI:10.32604/biocell.2022.015760
    Abstract Aberrant expression of miRNAs is significantly correlated with the occurrence of immune thrombocytopenic purpura (ITP). The immune imbalance of M1/M2 macrophage contributes to the development of ITP. However, the role of miR-148b-3p in macrophage phenotype imbalance remains unknown in ITP. In this study, we aimed to explore whether miR-148b-3p inhibits M2 macrophage polarization in ITP and to investigate the underlying mechanism. Peripheral blood from 22 ITP patients were collected, and real-time PCR confirmed that miR-148b-3p was up-regulated and Western blot analyses detected the expression of SOCS3 was down-regulated. Subsequent dual-luciferase reporter gene assay indicated that miR-148b-3p could bind to SOCS3.… More >

  • ARTICLE

    Platelet rich plasma–complexed hydrogel glue enhances skin wound healing in a diabetic rat model

    BIOCELL, Vol.46, No.5, pp. 1329-1338, 2022, DOI:10.32604/biocell.2022.015592
    Abstract Diabetic patients often exhibit delayed or incomplete progress in the healing of acute wounds, owing to poor blood perfusion. Platelet-rich plasma (PRP) has attracted much attention as a means to improve wound healing, because it contains high growth factor concentrations. However, the burst-like release of PRP growth factors results in a short half-life of these therapeutic proteins, thus greatly limiting the therapeutic effect. In this study, we prepared PRP from human umbilical cord blood and developed an in situ photocrosslinkable PRP hydrogel glue (HNPRP) by adding a photoresponsive hyaluronic acid (HA-NB) into PRP. The HNPRP hydrogel allowed for controlled release… More >

  • ARTICLE

    Mycorrhiza improves plant growth and photosynthetic characteristics of tea plants in response to drought stress

    BIOCELL, Vol.46, No.5, pp. 1339-1346, 2022, DOI:10.32604/biocell.2022.018909
    (This article belongs to this Special Issue: Mycorrhizal Fungal Roles in Stress Tolerance of Plants)
    Abstract Tea plants are sensitive to soil moisture deficit, with the level of soil water being a critical factor affecting their growth and quality. Arbuscular mycorrhizal fungi (AMF) can improve water and nutrient absorption, but it is not clear whether AMF can improve the photosynthetic characteristics of tea plants. A potted study was conducted to determine the effects of Claroideoglomus etunicatum on plant growth, leaf water status, pigment content, gas exchange, and chlorophyll fluorescence parameters in Camellia sinensis cv. Fuding Dabaicha under well-watered (WW) and drought stress (DS) conditions. Root mycorrhizal colonization and soil hyphal length were significantly reduced by the… More >

  • ARTICLE

    Genome-wide identification, characterization, and expression analysis of aluminum-activated malate transporter genes (ALMTs) in Gossypium hirsutum L.

    BIOCELL, Vol.46, No.5, pp. 1347-1356, 2022, DOI:10.32604/biocell.2022.018254
    Abstract Aluminum-activated malate transporters (ALMT) are widely involved in plant growth and metabolic processes, including adaptation to acid soils, guard cell regulation, anion homeostasis, and seed development. Although ALMT genes have been identified in Arabidopsis, wheat, barley, and Lotus japonicus, little is known about its presence in Gossypium hirsutum L. In this study, ALMT gene recognition in diploid and tetraploid cotton were done using bioinformatics analysis that examined correlation between homology and evolution. Differentially regulated ALMT genetic profile in G. hirsutum was examined, using RNA sequencing and qRT-PCR, during six fiber developmental time-points, namely 5 d, 7 d, 10 d, 15… More >

  • ARTICLE

    Oncolytic adenovirus targeting LASP-1 inhibited renal cell cancer progression

    BIOCELL, Vol.44, No.4, pp. 639-647, 2020, DOI:10.32604/biocell.2020.013053
    Abstract Recent studies suggested that LIM and SH3 protein 1 (LASP-1) is a promising therapeutic target for renal cell cancer (RCC). This study aimed to explore the role of LASP-1 in RCC. For this purpose, LASP-1 expression in RCC tissues was analyzed by immunohistochemistry and Western blot analysis. Cell proliferation, migration, invasion, and gene expression were detected by CCK-8 assay, Transwell assay, and Western blot analysis. The results showed that LASP-1 was highly expressed in RCC, and its expression level,t was positively correlated with lymph node metastasis and tumor, nodes, and metastases (TNM) stage. The knockdown of LASP-1 expression significantly inhibited… More >

  • ARTICLE

    Rapid delivery of Cas9 gene into the tomato cv. ‘Heinz 1706’ through an optimized Agrobacterium-mediated transformation procedure

    BIOCELL, Vol.45, No.1, pp. 199-215, 2021, DOI:10.32604/biocell.2021.012353
    (This article belongs to this Special Issue: )
    Abstract Solanum lycopersicum ‘Heinz 1706’ is a pioneer model cultivar for tomato research, whose whole genome sequence valuable for genomics studies is available. Nevertheless, a genetic transformation procedure for this cultivar has not yet been reported. Meanwhile, various genome editing technologies such as transfection of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) ribonucleoprotein complexes into cells are in the limelight. Utilizing the Cas9-expressing genotype possessing a reference genome can simplify the verification of an off-target effect, resolve the economic cost of Cas9 endonuclease preparation, and avoid the complex assembly process together with single-guide RNA (sgRNA) in the transfection approach. Thus,… More >

  • REVIEW

    Visualization of integrin molecules by fluorescence imaging and techniques

    BIOCELL, Vol.45, No.2, pp. 229-257, 2021, DOI:10.32604/biocell.2021.014338
    Abstract Integrin molecules are transmembrane αβ heterodimers involved in cell adhesion, trafficking, and signaling. Upon activation, integrins undergo dynamic conformational changes that regulate their affinity to ligands. The physiological functions and activation mechanisms of integrins have been heavily discussed in previous studies and reviews, but the fluorescence imaging techniques –which are powerful tools for biological studies– have not. Here we review the fluorescence labeling methods, imaging techniques, as well as Förster resonance energy transfer assays used to study integrin expression, localization, activation, and functions. More >

  • REVIEW

    The role of protein phosphorylation in the regulation of class switch recombination

    BIOCELL, Vol.44, No.4, pp. 545-558, 2020, DOI:10.32604/biocell.2020.012740
    Abstract Antibody is an important part of adaptive immune system and is produced only by B cells. There are five main classes (IgM, IgD, IgG, IgA, IgE) and some subclasses in antibodies. IgM and IgD are produced by mature naïve B cells. On the other hand, IgG, IgA and IgE are produced by activated antigen-specific B cells via class switch recombination (CSR). CSR is the irreversible DNA rearrangement from upstream to downstream classes in immunoglobulin heavy chain genes. Co-stimulations of CD40 ligand (CD40L) and cytokines are required for induction of CSR by activating several transcription factors. These signal transduction pathways involve… More >

  • REVIEW

    A hypothesis for a novel role of RIN1-the modulation of telomerase function by the MAPK signaling pathway

    BIOCELL, Vol.44, No.4, pp. 525-534, 2020, DOI:10.32604/biocell.2020.011407
    Abstract Cancerous cells display abnormalities in the signal transduction pathways responsible for responding to extracellular growth factors, or mitogens. Mutations that alter proteins involved in these types of pathways can lead to inappropriate or unregulated cell growth, and therefore predispose the cell to become malignant. The critical role of the Ras/mitogen-activated protein kinase (MAPK) pathway in transducing growth signals to the interior of the cell and subsequently stimulating cell growth and proliferation is underscored by the fact that roughly one quarter of all human tumors contain mutant forms of Ras proteins. A particular focus on the signaling and membrane trafficking adaptor… More >

  • ARTICLE

    Combinatory effect of hesperetin and mesenchymal stem cells on the deteriorated lipid profile, heart and kidney functions and antioxidant activity in STZ-induced diabetic rats

    BIOCELL, Vol.44, No.1, pp. 27-29, 2020, DOI:10.32604/biocell.2020.08040
    Abstract This study aimed to assess the effect of hesperetin and/or bone marrow-derived mesenchymal stem cells (BM-MSCs) on disturbed lipid profile, heart and kidney functions, oxidative stress and antioxidant defense system in streptozotocin (STZ)-induced diabetic rats. Type 1 diabetes mellitus (T1DM) was induced in male Wistar rats by injecting 40 mg/kg body weight (b.w.) STZ dissolved in citrate buffer (pH 4.5). The diabetic rats were treated with hesperetin orally administered at dose 20 mg/kg b.w., BM-MSCs intravenously injected at a dose of 1 x 106 cells/ rat/week and their combination for 6 weeks. The diabetic rats exhibited lipid abnormalities manifested by… More >

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